尽管对拟似脉络膜恶性黑色素瘤的病变已有更大的警觉,并且较为完善的检查方法业已发展,但是,在小的眼内肿瘤诊断上,错误仍不断发生。本文将讨论最重要的诊断问题之一:大脉络膜痣(nevus)与早期恶性黑色素瘤的鉴别。病原学概念在早期皮科文献中,“痣”这个词是指由任何一种或一群组织所组成的良性先天性肿瘤。现在它被皮科学家、眼科学家和病理学家用在较为狭义的范围,与“黑痣(mole)”或“良性黑色素瘤”为同一含义,用以描述起源于神经嵴的,由 Despite the increased vigilance on the pathology of the suspected choroidal malignant melanoma and the more sophisticated examination methods have been developed, errors continue to occur in the diagnosis of small intraocular tumors. This article will discuss one of the most important diagnostic issues: the identification of nevus and early malignant melanoma. The concept of etiology In the early pico literature, the term “mole” refers to a benign congenital neoplasm consisting of any one or a group of tissues. It is now used by the dermatologists, ophthalmologists and pathologists in a narrower sense of the same meaning as “mole” or “benign melanoma,” to describe the