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早在1911年Will Mayo氏已认为不少血液疾患可以采用脾切除来治疗,1935年Cooley氏等又提出了脾切除的临床指征,当时仅局限于溶血性贫血、血小板减少性紫癜及脾功能亢进。50年代以后对脾脏的功能有了新的认识使脾切除治疗血液疾患又被重视,随着脾切除治疗血液病的较广泛的采用,因而切脾以后对机体的影响必然引起临床工作者的重视,特别是有关切脾后严重感染(Overwhelming Postsplenectomy Infection简称OPSI)的问题。自从1951年King及Shumacher二氏报告5例6个月以下的婴儿脾切除后发生败血症或脑膜炎,1961年他们又提出了切脾后对细菌易感性的问题。以后国外文献对这问题陆续有报导,如Batroff及Nebehay氏报告1例肺球菌败血症伴有多种凝血缺陷,
As early as 1911, Will Mayo’s thought that many blood disorders could be treated by splenectomy. In 1935, Cooley et al. Proposed clinical indications for splenectomy, which were limited to hemolytic anemia, thrombocytopenic purpura and splenic function Kang. 50 years after the spleen has a new understanding of the function of spleen resection treatment of blood diseases have been taken seriously, with the splenectomy treatment of blood diseases more widely used, and thus the impact of the spleen after the body will inevitably attract the attention of clinicians , In particular with regard to the issue of Overwhelming Postsplenectomy Infection (OPSI). Since 1951, King and Shumacher II reported sepsis or meningitis in 5 infants less than 6 months after splenectomy. In 1961 they again raised the issue of bacterial susceptibility after splenectomy. After the foreign literature on this issue one after another have been reported, such as Batroff and Nebehay’s report of a case of pneumococcal sepsis with a variety of coagulation defects,