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目的:观察大黄联合EEN治疗重症急性胰腺炎(SAP)的疗效。方法:将73例SAP病人随机分为TPN组、EEN组和大黄联合EEN(REN)组。观察三组病人住院费用、住院时间、死亡人数、肠道功能恢复时间、APACHEⅡ评分,检测血浆降钙素原(PCT)、C-反应蛋白(CRP)、PA等,并进行比较。结果:REN组无一例死亡,EEN组死亡1例,TPN组2例;REN组病人的肠道功能恢复时间、平均住院天数和费用均低于其他两组(与TPN组比,P<0.01;与EEN组比,P<0.05)。治疗1周后,REN组APACHEⅡ评分和CRP明显下降(P<0.01);PCT阳性例数由21例下降为2例(P<0.01);TPN组PA显著上升(P<0.01)。结论:大黄联合EEN治疗SAP,能促进病人消化道功能恢复,改善病人的营养状况,降低炎性反应,缩短住院时间,减少医疗费用。
Objective: To observe the curative effect of rhubarb combined with EEN on severe acute pancreatitis (SAP). Methods: Seventy-three SAP patients were randomly divided into TPN group, EEN group and rhubarb combined with EEN (REN) group. The hospitalization cost, length of hospital stay, number of deaths, recovery time of intestinal function, APACHEⅡscore, plasma PCT, CRP and PA were observed and compared in three groups. Results: There was no death in REN group, 1 case died in EEN group and 2 cases in TPN group. The recovery time, average length of hospital stay and cost of intestinal function in REN group were lower than those in other two groups (P <0.01; Compared with EEN group, P <0.05). After 1 week of treatment, APACHEⅡscore and CRP in REN group decreased significantly (P <0.01); PCT positive number decreased from 21 cases to 2 cases (P <0.01); PA in TPN group increased significantly (P <0.01). Conclusion: Rhubarb combined with EEN treatment of SAP, can promote the recovery of patients with digestive tract function, improve the patient’s nutritional status, reduce inflammatory response, reduce hospital stay, reduce medical costs.