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目的 :观察食管鳞状细胞癌组织中微血管密度 (microvessel density,MVD) ,分析其与临床病理特征的关系和临床意义。方法 :采用免疫组织化学法 (imm unohistochem istry,IHC) ,检测 6 2例食管癌组织中微血管密度 ,并对其与临床病理特征的关系进行统计学分析。结果 :肿瘤组织 2 0 0倍视野内微血管计数平均值为 5 6 .32± 15 .4 1。肿瘤大小在 2 cm～ 5 cm和≥ 5 cm两组的 MVD与≤ 2 cm组相比 ,其差异分别具有显著性意义和非常显著性的意义 (P<0 .0 5和 P<0 .0 1) ;淋巴结转移 >3个者MVD显著高于淋巴结阴性者 (P<0 .0 1) ;复发转移者 MVD显著高于无病生存者 (P<0 .0 1) ;MVD与肿瘤的部位和组织学分级未见显著性差异 (P>0 .0 5 )。结论 :MVD与肿瘤的大小、淋巴结转移数目、复发转移密切相关 ,有可能成为食管癌的另一个预后预测因素。
Objective: To observe the microvessel density (MVD) in esophageal squamous cell carcinoma (HCC) and to analyze its relationship with clinicopathological features and clinical significance. Methods: The density of microvessels in 62 esophageal cancer tissues was detected by immunohistochemistry (IHC). The relationship between the microvessel density and clinicopathological features was analyzed. Results: The average microvessel counts in the 200 field of tumor tissues were 56.32 ± 15.41. The differences in MVD between 2 cm and 5 cm and ≥ 5 cm groups were significant and very significant (P <0.05 and P <0. 0), respectively 1). The MVD of lymph node metastasis> 3 was significantly higher than that of lymph node negative (P <0.01). The MVD of recurrence and metastasis was significantly higher than that of disease-free survival (P <0.01) And histological grade showed no significant difference (P> 0.05). Conclusions: MVD is closely related to tumor size, lymph node metastasis and recurrence and metastasis, which may be another prognostic factor for esophageal cancer.