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目的 探讨单相、双相抑郁患者静息态下皮质间功能连接脑磁图特征的差异.方法 对12例双相抑郁患者(双相抑郁组)、27例单相抑郁患者(单相抑郁组)和21名性别、年龄及受教育年限相匹配的健康对照者(对照组)进行静息态脑磁图扫描.采用同步似然性(synchronizationlikelihood,SL)值评估脑皮质功能连接,比较3组受试者θ、α1、α2、β及y频段各感兴趣脑皮质区半球内及半球间SL值,在方差分析的基础上进行两两样本post-hoc检验.结果 双相抑郁组较单相抑郁组及对照组左枕叶内部θ(0.249±0.087、0.181±0.029、0.196±0.032,F=8.511,P=0.001),α1(0.200±0.051、0.164±0.020、0.175±0.028,F=5.292,P=0.008)及α2(0.200±0.047、0.175±0.025、0.183±0.025,F=4.721,P=0.013)频段,右额叶内部β(0.186±0.027、0.166±0.024、0.159±0.026,F=4.195,P=0.020),γ(0.151 ±0.020、0.128±0.019、0.133±0.019,F=5.521,P=0.006)频段SL值升高.与对照组相比,双相抑郁组β(0.076±0.013与0.087±0.011,P=0.009)、γ(0.062±0.010与0.069±0.010,P=0.020)频段左右额叶间SL值增高,而单相抑郁组γ(0.057±0.013与0.050±0.005,P=0.009)频段右额叶-右顶叶顶区SL值下降.结论 双相抑郁患者较单相抑郁患者额-顶-枕区功能连接进一步损害,额叶及枕叶内部局部功能连接差异可能是区分单相、双相抑郁的特征之一.“,”Objective To explore the differences of cortico-cortical functional connectivity features among patients with bipolar and unipolar depression in resting-state.Methods Whole-head magnetoencephalography scan was performed in an resting-state condition in 12 bipolar depression patients,27 unipolar depression patients and 21 gender-,age-,level of education-matched healthy controls.The strength of cortico-cortical functional connections was measured with synchronization likelihood (SL) value,and the SL value of long-rage as well as short-rage within θ,α1,α2,β and γ frequency bands were compared in three groups.Group-wise two post-hoc t-test was performed according to the results of ANOVA.Results Compared with the unipolar depression patients and the controls,bipolar patients showed increased local θ (0.249±0.087,0.181±0.029,0.196±0.032; F=8.511,P=0.001); α1(0.200±0.051,0.164±0.020,0.175±0.028;F=5.292,P=0.008) and α2 (0.200± 0.047,0.175± 0.025,0.183 ± 0.025; F=4.721,P=0.013) SL in the left occipital lobe and local β (0.186±0.027,0.166±0.024,0.159±0.026; F=4.195,P=0.020) and γ (0.151±0.020,0.128±0.019,0.133±0.019; F=5.521,P=0.006) SL in right frontal lobe.Compared with the controls,the bipolar patients presented increased β (0.076±0.013 vs.0.087±0.011,P=0.009) and γ(0.062±0.010 vs.0.069±0.010,P=0.020) inter-hemispheric SL between bilateral frontal lobe,whereby the unipolar patients showed decreased γ(0.057 ± 0.013 vs.0.050 ± 0.005,P=0.009) band inter-hemispheric SL in the right frontal-parietal regions.Conclusions The bipolar depression patients displayed further dysfunction of cortical resting connectivity over the fronto-parieto-occipital regions than unipolar depression patients.The loss of temporal synchronization in the frontal and occipital lobe may be a biomarker to differentiate bipolar from unipolar depression.