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目的研究急性冠脉综合征(ACS)患者情绪焦虑抑郁状态与超敏C-反应蛋白(hs-CRP)的关系。方法连续收集2006年2月至2007年10月入住同济大学医学院附属同济医院、上海市第十人民医院、东方医院、上海市闸北区中心医院和上海市市东医院5所医院心血管内科病房的647例ACS患者,于入院时抽取外周静脉血,监测其发病36h以内血浆hs-CRP;患者入院7d内完成标准化问卷调查表《医院情绪抑郁及焦虑量表》(HADS)并计分,记录年龄、性别、冠心病危险因子及相关临床数据。结果焦虑组患者血浆hs-CRP显著低于非焦虑非抑郁组[(10.43±3.55)mg/L对(13.19±4.90)mg/L,P<0.05],抑郁组患者血浆hs-CRP显著高于非焦虑非抑郁组[(25.41±7.07)mg/L对(13.19±4.90)mg/L,P<0.05],焦虑抑郁共病组患者与非焦虑非抑郁组患者血浆hs-CRP差异无统计学意义[(14.62±5.01)mg/L对(13.19±4.90)mg/L,P>0.05]。结论ACS合并情绪抑郁程度与患者体内炎性反应活跃有关;而焦虑情绪与炎症反应活性之间无正相关关系。
Objective To investigate the relationship between depression and high sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS). Methods The patients admitted to Tongji Hospital, Tongji Hospital affiliated to Medical College of Tongji University, Shanghai Tenth People’s Hospital, Dongfang Hospital, Shanghai Zhabei District Central Hospital and Shanghai Shidong Hospital were recruited from February 2006 to October 2007. Of 647 patients with ACS were enrolled in this study. Peripheral venous blood was collected during admission and plasma hs-CRP was monitored within 36 hours after admission. The standardized questionnaire “Hypnosis and Anxiety Scale” (HADS) was completed within 7 days of admission and scored and recorded Age, gender, risk factors of coronary heart disease and related clinical data. Results The plasma hs-CRP level in anxiety group was significantly lower than that in non-anxiety and non-depression group [(10.43 ± 3.55) mg / L vs (13.19 ± 4.90) mg / L, P <0.05] There was no significant difference in plasma hs-CRP between non-anxiety and non-depression group [(25.41 ± 7.07) mg / L vs (13.19 ± 4.90) mg / L, P <0.05] Significance [(14.62 ± 5.01) mg / L versus (13.19 ± 4.90) mg / L, P> 0.05]. Conclusions There is no correlation between anxiety and inflammatory reaction in patients with ACS complicated with depression.