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目的 探讨血管紧张素转换酶 (ACE)基因多态性与非胰岛素依赖型糖尿病 (NIDDM )伴微血管病变的关系。方法 应用多聚酶链反应 (PCR)技术 ,对 15 1名NIDDM患者及 10 0名正常对照者的ACE基因插入 /缺失 (I/D)型多态性进行检测。结果 NIDDM患者DD型的发生频率明显高于正常人 (P <0 0 1) ;NIDDM伴糖尿病肾病者DD型发生频率明显高于无糖尿病肾病者 (P <0 0 5 ) ;NIDDM伴糖尿病眼底病变者DD型发生频率明显高于无糖尿病眼底病变者 (P <0 0 5 )。
Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and non-insulin dependent diabetes mellitus (NIDDM) with microvascular disease. Methods ACE gene insertion / deletion (I / D) polymorphism was detected in 15 1 NIDDM patients and 10 normal controls by polymerase chain reaction (PCR). Results The frequency of DD in NIDDM patients was significantly higher than that in normal controls (P <0.01). The frequency of DD in NIDDM patients with diabetic nephropathy was significantly higher than that in patients without diabetic nephropathy (P <0.05). NIDDM with diabetic retinopathy The frequency of DD type was significantly higher than those without diabetic retinopathy (P <0.05).