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目的考察大鼠体内姜黄素乙醇脂质体的药动学特点。方法大鼠灌胃给药,高效液相色谱法测定各血药浓度,采用DAS 2.1.1软件处理并分析药动学数据。结果在非室模型分析中,经计算姜黄素乙醇脂质体的0~72h曲线下面积〔AUC(0-72h)〕为游离姜黄素的1.6倍,其峰浓度Cmax为游离姜黄素的1.5倍,姜黄素乙醇脂质体的相对生物利用度为152.2%,姜黄素乙醇脂质体的AUC(0-72h)的90%可置信区间为102.2%~128.5%,不在生物等效性标准区间内。在室模型分析中,姜黄素乙醇脂质体的AUC(0-72h)为游离姜黄素的1.4倍,姜黄素乙醇脂质体的相对生物利用度为128.2%。结论姜黄素乙醇脂质体可提高口服生物利用度,且与游离姜黄素生物不等效。
Objective To investigate the pharmacokinetics of curcumin ethanol liposomes in rats. Methods The rats were intragastrically administrated and the plasma concentration of each drug was determined by HPLC. The pharmacokinetic data were analyzed by DAS 2.1.1 software. Results In the non-compartment model analysis, curcumin ethanol liposomes were calculated for the area under the curve from 0 to 72 h [AUC (0-72 h)] 1.6 times that of free curcumin and the peak concentration Cmax 1.5 times that of free curcumin , The relative bioavailability of curcumin ethanol liposomes was 152.2%, and the 90% confidence interval of curcumin ethanol liposomes AUC (0-72h) was 102.2% -128.5%, which was not within the bioequivalence standard interval . In the chamber model analysis, curcumin ethanol liposome AUC (0-72h) 1.4 times the free curcumin, curcumin ethanol liposome relative bioavailability was 128.2%. Conclusion Curcumin liposomes can improve oral bioavailability and are not equivalent to free curcumin.