目的探讨早期应用沐舒坦对预防早产儿肺透明膜病 (HMD)的效果。方法观察用药组与未用药组早产儿 HMD的发生率、病死率、并发症发生率 ,监测入院 6小时患儿的血气分析并进行比较。结果 1用药组与未用药组 HMD的发生率有显著性差异 (P<0 .0 5 ) ;2入院 6小时血气分析结果有显著差异。结论新生儿早期应用沐舒坦预防 HDM具有较好效果。 Objective To explore the effect of early application of ambroxol on preventing hyaline membrane disease (HMD) in preterm infants. Methods The incidence of HMD, mortality and complications in preterm infants treated with or without medication were observed, and blood gas analysis was performed in children 6 hours after admission. Results 1 There was a significant difference in the incidence of HMD between the medication group and the non-medication group (P <0. 05); 2 There was significant difference between the 6-hour blood gas analysis results. Conclusions Early use of ambroxol in neonatal prevention of HDM has a good effect.