目的:建立毛细管气相色谱法同时测定关节止痛膏中樟脑、薄荷脑和水杨酸甲酯含量的方法。方法:采用无水乙醇加热回流制备供试液,以萘为内标物,采用HP-5毛细管色谱柱(30 m×0.25 mm×0.25μm),FID检测器;氮气为载气;采用程序升温,内标法测定样品中3种成分的含量。结果:在此色谱条件下,樟脑、薄荷脑和水杨酸甲酯及内标物萘均得到良好的分离;樟脑、薄荷脑和水杨酸甲酯的加样回收率(n=6)分别为98.4%、99.2%和97.5%;用所建立的方法对8个不同厂家的产品进行含量测定,均取得满意的结果。结论:本法简便、灵敏、准确,重复性好,可用于该制剂的质量控制。 Objective: To establish a method for simultaneous determination of camphor, menthol and methyl salicylate in articular analgesic cream by capillary gas chromatography. Methods: The test solution was prepared by refluxing with anhydrous ethanol and using naphthalene as the internal standard. The sample was chromatographed on a HP-5 capillary column (30 m × 0.25 mm × 0.25 μm) with a FID detector and nitrogen as the carrier gas. , Internal standard method to determine the content of three components in the sample. Results: Under the chromatographic conditions, the naphthalene, camphor, menthol, methyl salicylate and internal standard naphthalene were well separated. The recoveries of camphor, menthol and methyl salicylate (n = 6) 98.4%, 99.2% and 97.5%, respectively. The results of eight different manufacturers’ products were determined by the established method, and satisfactory results were obtained. Conclusion: This method is simple, sensitive, accurate, reproducible, and can be used for the quality control of the preparation.