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心房颤动的发生和维持与心房重构有关。心房纤维化是心房颤动患者心房结构重构最突出的表现,目前被认为是发生心房颤动的结构基础,是心房颤动发生、维持的一个重要因素。现综述心房颤动患者心房纤维化及其发生机制。通过对心房颤动患者心房纤维化结构改变及肾素-血管紧张素系统、转化生长因子、基质金属蛋白酶等在心房纤维化的发生和心房颤动发生、维持中的作用等的全面阐述,,探讨了心房颤动患者心房纤维化的研究进展。防治心房颤动新的策略取决于对心房纤维化机制更好的理解。
The occurrence and maintenance of atrial fibrillation and atrial remodeling. Atrial fibrosis is the most prominent manifestation of atrial structural remodeling in patients with atrial fibrillation and is currently considered as the structural basis of atrial fibrillation and an important factor in the occurrence and maintenance of atrial fibrillation. Are summarized in patients with atrial fibrillation atrial fibrosis and its mechanism. Through atrial fibrillation in patients with structural changes of atrial fibrosis and renin - angiotensin system, transforming growth factor, matrix metalloproteinases and other occurrence of atrial fibrillation and atrial fibrillation, the role of maintenance and so on a comprehensive exposition, discussed Research Progress on Atrial Fibrosis in Patients with Atrial Fibrillation. A new strategy to combat atrial fibrillation depends on a better understanding of the mechanisms of atrial fibrosis.