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目的:观察不同期梅毒患者血清IL-2、4、6、10水平,探讨其在梅毒感染发生、发展中的意义。方法:选取显性梅毒患者80例,采用ELISA法检测血清IL-2、4、6、10含量,并以60例健康者作为对照组进行比较。结果:显性梅毒患者IL-2、IL-4、IL-6、IL-10均高于对照组,差异均有统计学意义(χ2=14.55、10.17、16.84、13.92,P<0.05);一期梅毒患者IL-2高于二期梅毒患者,但IL-4、IL-6、IL-10低于二期梅毒患者,差异均有统计学意义。IL-2与IL-4、IL-6、IL-10为负相关(r=-0.728、r=-0.709、r=-0.617,P<0.05);IL-4与IL-6、IL-10为正相关(r=0.812、r=0.902,P<0.05);IL-6与IL-10为正相关(r=0.748,P<0.05)。男性与女性IL-2、IL-4、IL-6、IL-10表达差异无统计学意义(均P>0.05);不同年龄段IL-2、IL-4、IL-6、IL-10表达差异有统计学意义(均P<0.05)。结论:梅毒感染者存在异常的细胞免疫应答,及其细胞因子分泌失调,联合检测IL-2、IL-4、IL-6、IL-10有助于分期判断与指导治疗。
Objective: To observe the levels of serum IL-2, 4, 6 and 10 in patients with syphilis at different stages and to explore its significance in the occurrence and development of syphilis infection. Methods: Eighty patients with dominant syphilis were selected. Serum levels of IL-2, 4, 6, and 10 were measured by ELISA, and 60 healthy controls were compared. Results: The levels of IL-2, IL-4, IL-6 and IL-10 in patients with dominant syphilis were significantly higher than those in controls (χ2 = 14.55,10.17,16.84,13.92, P <0.05) The level of IL-2 in patients with syphilis was higher than that in patients with secondary syphilis, but the levels of IL-4, IL-6 and IL-10 were lower than those of patients with syphilis, the differences were statistically significant. IL-2 was negatively correlated with IL-4, IL-6 and IL-10 (r = -0.728, r = -0.709, r = -0.617, (R = 0.812, r = 0.902, P <0.05). There was a positive correlation between IL-6 and IL-10 (r = 0.748, P <0.05). The expressions of IL-2, IL-4, IL-6 and IL-10 in males and females were not significantly different (all P> 0.05). The expressions of IL-2, IL-4, IL-6 and IL- The difference was statistically significant (all P <0.05). CONCLUSIONS: Syphilitic patients have abnormal cellular immune responses and cytokine secretion disorders. Combined detection of IL-2, IL-4, IL-6 and IL-10 contributes to staging and guidance therapy.