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目的:分析研究乙型肝炎患者血清中自身抗体检测的临床意义。方法:将2012年4月-2014年4月期间在本院接受治疗的100例乙型肝炎患者作为研究组,另取40例体检健康者为对照组,观察比较两组研究对象的血清中自身抗体的检测结果。结果:研究组乙型肝炎患者血清中比较常见的自身抗体为抗核杭体和抗平滑肌抗体,患者自身抗体的总阳性率为19.0%,明显高于对照组体检健康者的2.5%(P<0.05),而研究组慢性活动性的肝炎患者的总阳性率(18.1%)与肝硬化患者的总阳性率(21.4%)相比差异不具有统计学意义(P>0.05)。结论:乙型肝炎病毒感染会诱发患者出现自身免疫而产生多种自身抗体,对乙型肝炎患者血清中自身抗体进行检测具有一定的临床价值。
Objective: To analyze the clinical significance of the detection of autoantibodies in the serum of hepatitis B patients. Methods: One hundred patients with hepatitis B treated in our hospital from April 2012 to April 2014 were selected as the study group, and the other 40 healthy individuals were selected as the control group. The serum levels of the two groups were compared Antibody test results. Results: The most common autoantibodies in serum of patients with hepatitis B were antinuclear antibodies and anti-smooth muscle antibodies. The total positive rate of autoantibodies in patients with hepatitis B was 19.0%, which was significantly higher than 2.5% in healthy controls (P < 0.05). However, the total positive rate of chronic active hepatitis (18.1%) in study group was not significantly different from that of cirrhosis (21.4%) (P> 0.05). Conclusion: Hepatitis B virus infection will induce autoimmunity in patients with a variety of autoantibodies, serum autoantibodies in patients with hepatitis B has some clinical value.