背景目前世界上已有超过5亿人持续感染乙型肝炎和丙型肝炎病毒。尽管两种病毒不会直接造成细胞破坏,但是持续感染任一病毒均可能导致慢性肝炎,甚至发展为肝脂肪变性、肝硬化、肝衰竭和肝细胞癌。病毒特异性T细胞是肝炎演变过程中的主要决定因素之一,虽然它们对早期的慢性肝炎病 Background Currently, more than 500 million people in the world have been continuously infected with hepatitis B and hepatitis C virus. Although both viruses do not directly cause cell damage, continued infection with either virus can lead to chronic hepatitis and even to hepatic steatosis, cirrhosis, liver failure, and hepatocellular carcinoma. Virus-specific T cells are one of the major determinants of the evolution of hepatitis, although they have been associated with early chronic hepatitis