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江苏省启东县是我国肝癌高发区之一,1972～1982年肝癌年平均发病率和平均死亡率分别为50.33/10万和48.37/10万。在启东肝癌病因学研究中,苏德隆的工作表明启东肝癌死亡率随下列居民饮水类型而递增:井水、河水、泯沟、宅沟,他提出启东肝癌高发与居民饮用水质有关。黄曲霉毒素B_1(下称AFB_1)是人类肝癌另一个可能病因,AFB_1对实验动物的致癌作用又受某些营养素(如蛋白质、维生素A等)的影响。为今后进一步确证饮水和肝癌的关系,我们调查了启东不同饮水类型农村居民AFB_1和营养素摄入量的现状。
Qidong County of Jiangsu Province is one of the high-incidence areas of liver cancer in China. The average annual morbidity and average mortality rate of liver cancer in 1972 to 1982 were 50.33 per 100 000 and 48.37 per 100,000. In Qidong’s study of liver cancer etiology, Su Delong’s work showed that liver cancer mortality in Qidong increased with the type of drinking water of the following residents: well water, river water, ditch, ditch and ditch. He proposed that the high incidence of liver cancer in Qidong was related to the drinking water quality of residents. Aflatoxin B 1 (hereinafter referred to as AFB 1) is another possible cause of human liver cancer. The carcinogenic effect of AFB 1 on experimental animals is also affected by certain nutrients (such as protein, vitamin A, etc.). To further confirm the relationship between drinking water and liver cancer in the future, we investigated the status of AFB_1 and nutrient intake in rural residents of different drinking water types in Qidong.