目的:探讨分析经皮经肝硬质胆道镜取石术前后肝功能的变化。方法:回顾性分析广州医科大学附属第一医院2018年12月至2020年12月间，行经皮经肝硬质胆道镜取石术中符合纳入排除标准的29例患者临床资料，采用配对样本t检验方法，比较分析手术前后ALT、AST、GGT、TBA、ALB、PT、PA、FG等肝功能指标值的变化。结果:术后第1天，ALT、AST、PT均值均明显高于术前（P<0.05），而ALB、PA、FG均值较术前明显降低（P<0.05）。两月内首次复查，与术前相比，ALT、AST、GGT、TBA均值“,”Objective:To analyze the changes of liver function before and after Percutaneous transhepatic rigid cholangioscopic lithotripsy.Methods:The clinical data of 29 patients who met the research requirements during Percutaneous transhepatic cholangioscopic lithotripsy in the First Affiliated Hospital of Guangzhou Medical University from December 2018 to December 2020 were retrospectively analyzed.The paired sample t-test method was used to compare and analyze the changes of four liver function indexes（ALT、AST、GGT、TBA、ALB、PT、PA、FG）before and after surgery.Results:On the first day after operation，the mean values of ALT，AST and PT were significantly higher than those before operation（P<0.05)，while the mean values of ALB，PA and FG were significantly lower than those before operation（P<0.05).First review within two months，The mean values of ALT，AST，GGT and TBA were significantly lower than those before surgery（P<0.05）.Compared with the first day after surgery，the values of ALT，AST and PT were significantly decreased（P<0.05)，while the values of ALB，PA and FG were significantly increased（P<0.05).Conclusions:Although percutaneous transhepatobiliary lithotomy can cause transient damage to local liver tissues and cause temporary increase in ALT ，AST and PT values and temporary decrease in ALB，PA and Fg values，but the four liver function indexes of patients will be reduced to different degrees after the completion of the operation and removal of biliary tract obstruction，and even return to the normal range.