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目的:探讨抗精神病药致肉芽肿性乳腺炎（GM）的临床特点。方法:收集成都市妇女儿童中心医院抗精神病药相关GM病例，同时检索PubMed、Embase、ScienceDirect、万方、维普和中国知网数据库截至2019年11月收录的抗精神病药相关GM文献病例，收集这些病例的年龄、生育状况、原患精神疾病、致病药物、服药时间、乳房肿块的诊断和特点、血清催乳素水平、干预措施及预后等信息进行回顾性分析。结果:共收集抗精神病药相关GM临床病例7例和文献病例9例，均为女性，年龄为21~55岁，其中10例未生育。服用抗精神病药的时间为0.5~17.0年。16例患者中有8例患者的致病药物中含有利培酮，其他抗精神病药包括奥氮平、氯氮平、舒必利、阿立哌唑、奋乃静、喹硫平、氨磺必利、氟哌噻吨美利曲辛等。12例患者血清催乳素升高（25.45~84.50 μg/L），3例患者催乳素水平正常，1例文献未提及。9例患者手术切除病灶，其余7例患者调整或未调整抗精神病药，给予溴隐亭和/或甲泼尼龙口服治疗后GM明显好转，随访中发现1例复发患者。结论:抗精神病药相关GM可发生于任何年龄的女性，无论其是否生育。利培酮是导致GM的主要抗精神病药。“,”Objective:To explore the clinical characteristics of granulomatous mastitis (GM) induced by antipsychotics.Methods:Antipsychotic-related GM cases were collected in Chengdu Women′s and Children′s Central Hospital. Meanwhile, antipsychotic-related GM literature cases in PubMed, Embase, ScienceDirect, Wanfang, VIP, and CNKI databases up to November 2019 were searched. The age, fertility status, primary mental disease, causative agents, duration of medication, diagnosis and characteristics of breast lumps, serum prolactin level, intervention measures, and prognosis of these patients were collected and analyzed retrospectively.Results:A total of 7 clinical patients and 9 literature cases with antipsychotic drug-related GM were collected, and all of them were female, aged 21-55 years, of which 10 patients were never giving birth. They took antipsychotics for 0.5-17.0 years. The causative drugs included risperidone in 8 of the 16 patients. Other antipsychotics included olanzapine, clozapine, sulpiride, aripiprazole, perphenazine, quetiapine, amisulpride, flupentixol and melitracen, and etc. Serum prolactin levels elevated in 12 patients (25.45-84.50 μg/L), were normal in 3 patients, and were not mentioned in 1 patient. Surgical resection was performed in 9 patients. GM were improved significantly in the remaining 7 patients with or without adjusting antipsychotics after receiving oral administration of bromocriptine and/or methylprednisolone. And GM recurred in 1 patient during the followed-up.Conclusion:Antipsychotic-related GM may occur in women of any age, regardless of whether they have giving birth. Risperidone is the main antipsychotic drug causing GM.