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目的探讨成都市新诊断2型糖尿病(T2DM)的临床特征。方法选取四川省人民医院内分泌科门诊新诊断的T2DM患者177例,收集人口学资料、血压、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、血脂、肝肾功能等数据进行统计学分析。结果 177例患者中,合并超重者52.5%、肥胖者15.9%、高血压者57.3%、脂代谢紊乱者84.2%。与女性相比,男性发病率更高,起病年龄更年轻,具有更高的FBG、Hb A1c、血尿酸(UA)、舒张压(DBP)及谷丙转氨酶(ALT)水平以及更低的高密度脂蛋白(HDL)水平。与中老年患者相比,青年患者腰围、UA、ALT水平更高,HDL水平更低;但前者收缩压更高。BMI越高者,DBP、TG、ALT水平越高,而HDL水平越低。结论新诊断T2DM患者好发于45岁以上中年人,有合并多种代谢紊乱且有性别差异,肥胖者更易合并舒张压升高及脂代谢紊乱等临床特点。
Objective To investigate the clinical features of newly diagnosed type 2 diabetes mellitus (T2DM) in Chengdu. Methods A total of 177 newly diagnosed T2DM patients in the Department of Endocrinology of Sichuan Provincial People’s Hospital were enrolled in this study. Demographic data, blood pressure, fasting blood glucose (FBG), HbA1c, lipids, liver and kidney function were collected for statistical analysis. Results Of the 177 patients, 52.5% were overweight, 15.9% were obese, 57.3% were hypertensive, and 84.2% were lipid disorders. Compared with women, males have a higher morbidity, younger onset age, higher FBG, Hb A1c, UA, DBP and ALT levels and lower high Density lipoprotein (HDL) levels. Compared with the elderly patients, young patients with waist circumference, UA, ALT levels higher, lower HDL levels; but the former systolic blood pressure higher. Higher BMI, DBP, TG, ALT levels higher, while the lower the level of HDL. Conclusions Newly diagnosed T2DM patients occur mainly in middle-aged people over the age of 45, with many metabolic disorders and gender differences, obesity is more likely to be associated with increased diastolic blood pressure and lipid metabolism and other clinical features.