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目的 研究心理干预与复发性流产(recurrent spontaneous abortion,RSA)的关系。方法 选取2008年8月至2011年8月中山博爱医院妇产科收治的有复发性流产病史的先兆流产安胎患者200例,其中行心理干预100例为观察组,未行心理干预100例为对照组。用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)及免疫放射法测定血清考的松(Cortisol)、血清孕酮(progesterone,P)、催乳素(prolactin,PRL)及人绒毛膜促性腺激素(human chorionic gonadotrophin,HCG)值,观察妊娠结局并对新生儿进行评估,分别进行新生儿行为神经测定(neonatal behavio-ral neurological assessment,NBNA)及神经元烯醇化酶(neuron specif-ic enolase,NSE)水平测定。结果 观察组患者血清中抗考的松含量、抑郁自评量表(self-rating depression scale,SDS)评分、汉密顿抑郁量表(Hamilton rating scale for depression,HAMD)评分明显高于C组(P<0.05),行心理干预后上述指标改善(P<0.05)。结论 心理干预对改善复发性流产患者妊娠结局及新生儿预后有较好的影响。
Objective To study the relationship between psychological intervention and recurrent spontaneous abortion (RSA). Methods From August 2008 to August 2011, Zhongshan Boai Hospital Obstetrics and Gynecology admitted to the history of recurrent miscarriage of threatened abortion in patients with tocolysis 200 cases, of which 100 cases of psychological intervention for the observation group, 100 cases without psychological intervention Control group. Serum cortisol, progesterone (P), prolactin (PRL) and human chorionic gonadotropin (HGH) were measured by enzyme linked immunosorbent assay (ELISA) (neonatal behavioral ral neurological assessment (NBNA)) and neuron-specific enolase (NSE) were observed and the neonatal outcome was observed after treatment with human chorionic gonadotrophin (HCG) ) Determination of the level. Results In the observation group, the serum levels of anti-test pine, SDS-score and Hamilton rating scale for depression (HAMD) were significantly higher than those in C P <0.05), the above indicators improved after psychological intervention (P <0.05). Conclusions Psychological intervention has a good effect on improving pregnancy outcome and prognosis of recurrent spontaneous abortion.