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ARCaP细胞系是在转移前列腺癌患者腹水中建立的细胞系。该项研究鉴定了宿主微环境对ARCaP及ARCaP来源的细胞亚克隆在肿瘤演进,上皮细胞间质转化(EMT)及肿瘤向骨和肾上腺转移中的作用。研究者比较了ARCaP各亚克隆在细胞遗传特点、生长、迁移、侵袭、细胞间相互作用、药物敏感性
The ARCaP cell line is a cell line established in ascites of patients with metastatic prostate cancer. This study identified the role of host microenvironment in subcellular cloning of ARCaP- and ARCaP-derived cells in tumor progression, epithelial mesenchymal transition (EMT), and tumor metastasis to the bone and adrenals. The authors compared the subclones of ARCaP in cytogenetic characteristics, growth, migration, invasion, cell-cell interactions, drug sensitivity