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目的:探讨沙库巴曲缬沙坦钠片治疗慢性心力衰竭患者的临床疗效及对心功能和血清B型利钠肽(BNP)水平变化的影响。方法:选择2017年12月至2019年2月浙江绿城心血管病医院收治的慢性心力衰竭患者102例，按照随机数字表法分为对照组和治疗组，每组51例。对照组采用常规治疗，治疗组在常规治疗基础上联合沙库巴曲缬沙坦钠片治疗。两组疗程均为12周。比较两组治疗疗效，治疗前后心功能[包括左室射血分数(LVEF)、每搏心输出量(SV)和左心室舒张末内径(LVEDD)]、血清BNP、6 min步行距离(6MWD)及生活质量改善情况。结果:治疗组治疗总有效率为94.12%(48/51)，高于对照组的72.55%(37/51)，差异有统计学意义(χn 2＝8.541，n P<0.05)。治疗组治疗后LVEF[(60.28±6.97)%]和SV[(78.91±4.23)mL]高于对照组[(52.31±4.56)%和(71.35±6.74)mL]，而LVEDD[(54.89±5.26)mm]低于对照组[(61.74±4.80)mm]，差异均有统计学意义(n t＝6.834、6.785、6.870，均n P<0.05)。治疗组治疗后血清BNP水平[(164.32±14.39)ng/L]低于对照组[(248.96±23.15)ng/L]，而6MWD[(353.27±42.26)m]高于对照组[(273.21±34.47)m]，差异均有统计学意义(n t＝22.175、10.484，均n P<0.05)。治疗组治疗后明尼苏达生活量表(MLHFQ)评分[(27.83±5.41)分]低于对照组[(41.98±7.64)分]，差异有统计学意义(n t＝10.794，n P<0.05)。n 结论:沙库巴曲缬沙坦钠片治疗慢性心力衰竭患者临床疗效良好，可改善患者心功能，降低血清BNP水平，值得临床推广应用。“,”Objective:To investigate the clinical efficacy of sakubattral and valsartan sodium tablets in the treatment of heart failure and its effect on cardiac function and serum B-type natriuretic peptide(BNP).Methods:From December 2017 to February 2019, 102 patients with heart failure admitted to Lyucheng Cardiovascular Hospital of Zhejiang Province were selected and divided into control group and treatment group according to random number table method, with 51 cases in each group.The control group was treated with routine treatment, while the treatment group was treated with sakubattral and valsartan sodium tablets on the basis of routine treatment.Both two groups were treated for 12 weeks.The heart function[including left ventricular ejection fraction(LVEF), cardiac output per stroke(SV) and left ventricular end-diastolic diameter(LVEDD)], serum BNP, 6-minute walking distance(6MWD) and quality of life were compared between the two groups before and after treatment.Results:The total effective rate of the treatment group was 94.12%(48/51), which was higher than 72.55%(37/51) of the control group, the difference was statistically significant(χn 2=8.541, n P<0.05). After treatment, the LVEF[(60.28±6.97)%] and SV[(78.91±4.23)mL] in the treatment group were higher than those in the control group[(52.31±4.56)% and (71.35±6.74)mL], while the LVEDD in the trentment group [(54.89±5.26)mm]was lower than that in the control group[(61.74±4.80)mm], the differences were statistically significant(n t=6.834, 6.785, 6.870, all n P<0.05). After treatment, the serum BNP level in the treatment group[(164.32±14.39)ng/L] was lower than that in the control group[(248.96±23.15)ng/L], while the 6MWD in the trentment group [(353.27±42.26)m] was higher than that in the control group[(273.21±34.47)m], the differences were statistically significant (n t=22.175, 10.484, all n P<0.05). After treatment, the MLHFQ score in the treatment group[(27.83±5.41)points] was lower than that in the control group[(41.98±7.64)points], the difference was statistically significant(n t=10.794, n P<0.05).n Conclusion:Sakubattral and valsartan sodium tablets has good clinical efficacy in treating heart failure, it can improve cardiac function and reduce serum BNP level, which is worthy of clinical application.