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目的研究丙肝患者血清HCV-RNA含量和ALT浓度的关系。方法采用荧光定量PCR法检测296例疑似HCV感染患者的血清HCV-RNA,ELISA法检测抗-HCV,全自动生化分析仪测定ALT。结果296例血清标本中,HCV-RNA和抗-HCV均阳性155例,HCV-RNA阳性而抗-HCV阴性的9例,HCV-RNA阴性而抗-HCV阳性的67例。HCV-RNA含量和ALT浓度水平相关性不显著。结论HCV-RNA和抗-HCV的检测是诊断HCV-RNA感染的重要指标。但HCV-RNA含量和ALT浓度水平无明显相关。
Objective To study the relationship between serum HCV-RNA level and ALT concentration in hepatitis C patients. Methods Serum HCV-RNA was detected by fluorescence quantitative PCR in 296 patients with suspected HCV infection, anti-HCV by ELISA and ALT by automatic biochemical analyzer. Results Of the 296 serum samples, 155 were positive for HCV-RNA and anti-HCV, 9 were HCV-RNA positive and negative for anti-HCV, and 67 were HCV-RNA negative and anti-HCV positive. The correlation between HCV-RNA content and ALT concentration was not significant. Conclusion The detection of HCV-RNA and anti-HCV is an important index in the diagnosis of HCV-RNA infection. However, there was no significant correlation between HCV-RNA level and ALT concentration.