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目的了解脂蛋白脂酶 (L PL)基因 Pvu 位点多态性与肥胖代谢综合征的关系。方法对北京市西城区 2 11例超重 (BMI≥ 2 5 )和 93例体重正常的中老年人 (33～ 78岁 )进行 L PL- Pvu 位点多态性分析、体格检查及血生化指标检测。结果超重组与体重正常组 L PL- Pvu 位点基因型构成差异无显著性意义。L PL- Pvu 位点 (- /- )基因型携带者腰臀比低于 (+/+)基因型 ,HDL- C水平高于 (+/+)型 ,舒张压水平高于 (+/- )基因型 (P<0 .0 5 )。多因素分析显示腰臀比在 (+/+)、(+/- )和 (- /- )三种基因型间递减。结论 L PL基因 Pvu 位点 (- /- )基因型与腰臀比降低及 HDL- C水平升高有关 ,是肥胖代谢综合征的保护因素。
Objective To investigate the relationship between polymorphism of Pvu locus in lipoprotein lipase (LPL) gene and obesity metabolic syndrome. Methods Two hundred and seventy patients with overweight (BMI≥25) and 93 normal weight middle-aged and elderly (33-78 years old) in Xicheng District of Beijing were analyzed for LPL-Pvu locus polymorphism, physical examination and blood biochemical markers . Results There were no significant differences in the genotypes of L PL-Pvu locus between the overweight group and the normal weight group. HDL-C was higher than that of (+ / +) and LDH was higher than (+/-) in LPL-Pvu (- / -) genotype carriers ) Genotype (P <0.05). Multivariate analysis showed a decrease in waist-hip ratio among (+ / +), (+/-) and (- / -) genotypes. Conclusion The Pvu locus (- / -) genotype of LPL gene is related to the decrease of waist-to-hip ratio and the increase of HDL-C, which is the protective factor of obesity metabolic syndrome.