The discovery of new-type ore deposits, an important approach to guarantee the mineral resources supply in the 21st century, often brings about a gigantic increase in the mineral resources reserves. The analysis of mineralization system is of great importance to the discovery of new-type ore deposits. ① The understanding of the relationship among various ore deposit types within a mineralization system in a region can help us to locate the unknown ore deposit types from the known ore deposit types, evidence that has been proved in the mineral prospecting history of ore belts in the middle and lower reaches of the Yangtze River, China. ② The understanding of the spatial structure of a mineralization system, especially of the vertical zonation, is helpful for the discovery of the concealed ore deposit types. ③ Clarifying the temporal structure of a mineralization system, including the iteration relationship between the mineral deposit types in the mineralization, leads to the location of the missing mineralization chains from the known mineralization chains (mineral deposit type), a method often proved to be effective in the magmatic-hydrothermal mineralization system. ④ Clarifying the factors restraining the diversity of mineral deposit types in mineralization system leads to the discovery of the potential of new-type mineral deposits in relevant region. ⑤ Studying new mineralization setting and new ore-forming processes leads to discovery of new-type mineral deposit. More probabilities of discovery of new-type mineral deposits are present in biogenic mineralization system, deep-sea mineralization system, low-temperature mineralization system, tectonic mineralization system and superimposed mineralization system.