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目的:研究以硝酸咪康唑、地塞米松、丹皮酚为主药的咪松酚乳膏处方及其制备工艺。方法:实验通过油相(硬脂酸:液体石蜡:凡士林)量、乳化剂(三乙醇胺:单甘酯)量、水相(甘油:水)量、乳化温度等为影响因素,以综合质量评定为评价指标,采用正交设计试验,优选咪松酚乳膏处方及其制备工艺。结果:优选工艺为油相(硬脂酸:液体石蜡:凡士林)量为2:1.5:1.0,乳化剂(三乙醇胺:单甘酯)量为0.2:2,水相(甘油:水)量为10:30,乳化温度为80℃。结论:筛选的工艺制备出的乳膏质量稳定,操作简单。
Objective: To study the preparation of micomnol cream with miconazole nitrate, dexamethasone and paeonol as the main drugs. Methods: The experiment was carried out by using the amount of oil phase (stearic acid: liquid paraffin: petrolatum), the amount of emulsifier (triethanolamine: monoglyceride), the amount of water phase (glycerol: water) and the emulsifying temperature. For the evaluation of indicators, the orthogonal design test, preferably moxifloxyprogester cream prescription and its preparation process. Results: The optimum conditions were as follows: the amount of emulsifier (triethanolamine: monoglyceride) was 0.2: 2, the amount of water phase (glycerol: water) was 2: 1.5: 10:30, emulsifying temperature is 80 ℃. Conclusion: The cream prepared by the screening process has stable quality and easy operation.