高蛋白饮食可增加肾小球的高灌注和高滤过 ,引起肾肥大 ,导致肾损害。糖尿病肾病肾组织的特征性病理改变 ,是单核 /巨噬细胞在肾小球和肾间质内的浸润 ,并促进肾小球硬化。目前认为 ,高蛋白饮食、单核 /巨噬细胞在肾小球和肾间质的浸润、细胞间粘附分子 1(ICAM 1)的高表达 ,在糖尿病肾病的发生发展中起重要作用。高蛋白饮食引起的高滤过是引起ICAM 1高表达的潜在机制 High-protein diet can increase the high glomerular perfusion and hyperfiltration, causing kidney hypertrophy, leading to kidney damage. Diabetic nephropathy kidney tissue characteristic pathological changes, monocytes / macrophages in the glomerular and renal interstitial infiltration, and promote glomerular sclerosis. It is currently believed that high protein diet, monocyte / macrophage infiltration in the glomerular and renal interstitium, high expression of intercellular adhesion molecule 1 (ICAM 1) plays an important role in the occurrence and development of diabetic nephropathy. High-protein diet-induced hyperfiltration is a potential mechanism responsible for the high expression of ICAM 1