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目的高血压病患者血管健康维护,动脉粥样硬化的预防,应从血管病变的早期抓起,探讨降压治疗对血管健康维护的重要性。方法研究人群为我院2007～2010年以来的门诊及住院的高血压病患者,在12个月治疗高血压病的同时,治疗前后进行血压监测[包括收缩压(SBP)、舒张压(DBP)、脉压(PP)]、脉搏波传导速度(PWV)、心踝血管指数(CAVI)、踝臂指数(ABI)、颈总动脉内中膜厚度(IMT)及动脉僵硬系数(β),同时常规检测心电图、肾功、血脂、血糖等指标变化。并按照不同年龄段分组(共5组,分别为<40岁组、40～49岁组、50～59岁组、60～69岁组、≥70岁组)进行统计分析。结果各组治疗后SBP和DBP显著下降(P<0.001),PP缩小(P<0.001),血脂、血糖、肾功均无明显变化。PWV减慢(P<0.001)、CAVI下降(P<0.05)、ABI升高(P<0.05)、IMT变薄(P<0.05),β降低(P<0.01)。结论高血压病患者的动脉血管健康维护,从各个年龄组统计指标来看,降压治疗能够改善动脉功能,防治或延缓动脉粥样硬化的发生。
Objective Vascular health maintenance, prevention of atherosclerosis in patients with hypertension should start from the early stage of vascular disease, to explore the importance of antihypertensive treatment of vascular health maintenance. Methods The study population consisted of outpatient and inpatient hypertensive patients from 2007 to 2010 in our hospital. Blood pressure monitoring (including systolic blood pressure (SBP) and diastolic blood pressure (DBP)) was performed before and after treatment for 12 months. , Pulse pressure (PP)], PWV, CAVI, ABI, carotid IMT, and arterial stiffness (β) Routine detection of ECG, renal function, blood lipids, blood glucose and other indicators change. The patients were divided into groups according to different age groups (5 groups, <40 years old, 40 ~ 49 years old, 50 ~ 59 years old, 60 ~ 69 years old, ≥70 years old). Results SBP and DBP decreased significantly (P <0.001) and PP decreased (P <0.001) after treatment in each group. There was no significant change in serum lipids, blood glucose and renal function. PWV decreased (P <0.001), CAVI decreased (P <0.05), ABI increased (P <0.05), IMT decreased (P <0.05) and β decreased (P <0.01). Conclusion Arterial vascular health maintenance in patients with hypertension, from all age groups, statistical indicators, antihypertensive treatment can improve arterial function, prevent or delay the occurrence of atherosclerosis.