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目的:对新诊断II型糖尿病患者进行胰岛素联合黄芪消渴方治疗效果对比研究。方法:120例患者采用随机数字法分为两组,对照组60例患者采用单纯胰岛素治疗,观察者60例患者采用胰岛素联合黄芪消渴方治疗,比较两组患者的血糖水平与控制血糖的临床疗效情况。结果:观察组(胰岛素联合黄芪消渴方)患者的空腹血糖、餐后2h血糖值以及糖化血红蛋白值均低于对照组(单纯使用胰岛素)患者水平,两组比较差异具有统计学意义(P<0.05)。同时将治疗后与治疗前比较,两组患者体重指数变化无显著性差异,而空腹血糖、餐后2 h血糖以及糖化血红蛋白值治疗后均降低,差异具有统计学意义(P<0.05)。观察组患者治疗1个周后的空腹血糖达标率与餐后2h血糖达标率以及糖化血红蛋白达标率均高于对照组患者,两组比较差异具有统计学意义(P<0.05)。观察组未出现低血糖事件,对照组有2例出现低血糖情况,经简单处理恢复,两组均未出现严重的不良事件。观察组的达标时间以及胰岛素的用量均低于对照组,两组比较差异具有统计学意义(P<0.05)。结论:胰岛素联合黄芪消渴方对于新诊断2型糖尿病患者治疗依从性高,并且临床疗效好、安全性高。
OBJECTIVE: To compare the therapeutic effect of insulin combined with Huangqi Xiaoke Recipe in patients with newly diagnosed type II diabetes mellitus. Methods: One hundred and twenty patients were divided into two groups by random number method. In the control group, 60 patients were treated with insulin alone. The observer was treated with insulin combined with Huangqi Xiaoke Decoction. The blood glucose level was compared with that of blood glucose control group Efficacy. Results: The fasting blood glucose, 2h postprandial blood glucose and HbA1c in patients in the observation group (insulin combined with Huangqi Xiaoke Recipe) were lower than those in the control group (insulin only), the difference between the two groups was statistically significant (P < 0.05). At the same time, there was no significant difference in body mass index between the two groups after treatment and before treatment, while the fasting blood glucose, postprandial 2-h blood glucose and HbA1c were decreased after treatment, the difference was statistically significant (P <0.05). The fasting blood glucose compliance rate, the 2h postprandial blood glucose compliance rate and the HbA1c compliance rate in the observation group were higher than those in the control group after 1 week of treatment. The difference between the two groups was statistically significant (P <0.05). Hypoglycemia events did not occur in the observation group, and hypoglycemia in 2 cases in the control group. After simple treatment, no serious adverse events occurred in both groups. The observation group’s compliance time and the amount of insulin were lower than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion: The combination of insulin and Huangqi Xiaoke Fang has high compliance with newly diagnosed type 2 diabetes patients and has good clinical efficacy and high safety.