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116例T2DM通过询问入睡习惯,将患者分为A组23例(晚9点以前)、B组48例(晚9~10点)、C组45例(晚10点以后)。在原治疗基础上睡前中效胰岛素(诺和灵N)补充治疗,经1月剂量调整、2月剂量维持治疗后,治疗后FPG:A组与B组、C组(P<0.05),B组与C组相比(P>0.05);2hPBG:各组间相比(P>0.05);HbA1c:A组与B组(P<0.05),B组与C组(P>0.05),A组与C组(P<0.01)。胰岛素用量:A组与B、B组与C组(P<0.05),A组与C组(P<0.01)。轻微低血糖分别为8/23、7/48、5/45,有明显差别。结论:9pm至11pm尤其是10pm至11pm为睡前中效胰岛素补充治疗的最适注射时段。
One hundred and sixty-six patients with T2DM were divided into group A (n = 23), group B (n = 48) (n = 9-10) and group C (n = 45) after 10 o’clock. On the basis of the original treatment, the bedtime preemptive insulin (norepinephrine N) was supplemented. After the dose adjustment in January and the dose maintenance treatment in February, FPG: A group was significantly lower than that of the B group, C group (P <0.05) (P> 0.05); 2hPBG: compared to each group (P> 0.05); HbA1c: A group and B group (P <0.05), B group and C group Group and C group (P <0.01). Insulin dosage: A group and B, B group and C group (P <0.05), A group and C group (P <0.01). Mild hypoglycemia were 8 / 23,7 / 48,5 / 45, there are significant differences. Conclusion: 9pm to 11pm, especially 10pm to 11pm, is the optimal injection period for bedtime preemptive insulin replacement therapy.