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白细胞介素18(IL-18)作为一种前炎症细胞因子,参与了2型糖尿病及其微血管病变的发生、发展。IL-18在胰岛素抵抗及糖尿病病程的发展,可能起到中心介质的作用。IL-18水平变化不但对2型糖尿病及其微血管并发症的预后和临床治疗的评估有一定的价值,也为防治糖尿病及其并发症提供了新的研究方向。现就IL-18与2型糖尿病及其微血管病变的相关性做一综述。
As a pro-inflammatory cytokine, interleukin 18 (IL-18) is involved in the development and progression of type 2 diabetes mellitus and its microangiopathy. IL-18 in the development of insulin resistance and diabetes course may play a central role in the medium. The change of IL-18 not only has certain value for the evaluation of prognosis and clinical treatment of type 2 diabetes mellitus and its microvascular complications, but also provides a new research direction for the prevention and treatment of diabetes mellitus and its complications. Now IL-18 and type 2 diabetes and its microvascular disease are reviewed.