结核分枝杆菌的细菌型与L型(细胞壁缺陷型)的耐药,尤其是多重耐药和泛耐药现象对现有的临床抗结核治疗提出了严峻挑战。本文对结核分枝杆菌细菌型和L型耐药机制,以及中草药茜草素的抗菌作用进行了分析,以期建立有效的抗结核治疗方法,提高临床抗结核治疗水平。 Mycobacterium tuberculosis bacterial and L-type (cell wall defects) resistance, especially multi-drug resistance and pan-drug resistance of existing clinical anti-TB treatment poses a serious challenge. In this paper, the bacterial and L-type resistance mechanisms of Mycobacterium tuberculosis as well as the antibacterial effect of the Chinese herbal medicine, phletilisin were analyzed in order to establish an effective anti-TB treatment and improve the clinical anti-TB treatment.