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用ＲＡＲ受体选择性视黄酸和ＲＸＲ受体选择性视黄酸处理乳腺癌细胞，结果表明，ＲＡＲ受体选择性视黄酸能够有效地抑制依赖激素的乳腺癌细胞的生长，而ＲＸＲ受体选择性视黄酸则有效地抑制非依赖激素的乳腺癌细胞的生长．视黄酸的作用主要由其受体ＲＡＲｓ和ＲＸＲｓ所介导，ＲＮＡ印迹表明ＲＡＲα和ＲＡＲβ可能参与介导视黄酸的作用；进一步实验表明，通过ＲＡＲａ基因的转染，可以在非依赖激素的乳腺癌细胞中诱导ＲＡＲβ高水平地表达，使ＲＡ抗性细胞变为ＲＡ敏感细胞，因此，视黄酸诱导的ＲＡＲβ表达与其抑制乳腺癌细胞生长密切相关．
RAR receptor-selective retinoic acid and RXR receptor selective retinoic acid treatment of breast cancer cells, the results show that RAR receptor selective retinoic acid can effectively inhibit hormone-dependent breast cancer cell growth, and RXR by Body-selective retinoic acid effectively inhibits the growth of hormone-independent breast cancer cells. The effect of retinoic acid was mainly mediated by its receptors RARs and RXRs. Northern blotting indicated that RARα and RARβ may be involved in the mediation of retinoic acid. Further experiments showed that transfection of RARa gene could be used in hormone-independent RARβ is highly expressed in breast cancer cells and RA-resistant cells become RA-sensitive cells. Therefore, retinoic acid-induced RARβ expression is closely related to its inhibition of breast cancer cell growth.