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目的分析丹红注射液联合前列地尔治疗老年心功能不全伴不稳定型心绞痛的疗效。方法 87例老年心功能不全伴不稳定型心绞痛患者,按照不同治疗方案分为对照组(40例)和观察组(47例),对照组单纯给予前列地尔治疗,观察组采用前列地尔联合丹红注射液治疗,比较两组治疗前后血流动力学指标变化及安全性。结果治疗后两组左心室射血分数(LVEF)、心排出量(CO)、心脏指数(CI)及心肌工作指数(MPI)较治疗前均明显提高,且观察组提高幅度大于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率为6.38%,与对照组的15.00%比较,差异无统计学意义(P>0.05)。结论老年心功能不全伴不稳定型心绞痛患者行丹红注射液联合前列地尔治疗,可有效改善患者心功能,且不良反应少,值得临床推广应用。
Objective To analyze the efficacy of Danhong injection combined with alprostadil in the treatment of senile cardiac dysfunction with unstable angina pectoris. Methods Eighty-seven elderly patients with cardiac dysfunction and unstable angina pectoris were divided into control group (40 cases) and observation group (47 cases) according to different treatment regimens. The control group was treated with alprostadil alone. The observation group was treated with alprostadil Danhong injection treatment, changes in the two groups before and after treatment of hemodynamic indicators and safety. Results The left ventricular ejection fraction (LVEF), cardiac output (CO), cardiac index (CI) and myocardial function index (MPI) were significantly increased in both groups after treatment, and the improvement in the observation group was greater than that in the control group Statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 6.38%, which was not significantly different from that in the control group (15.00%) (P> 0.05). Conclusions Danhong injection combined with alprostadil in elderly patients with unstable heart angina and unstable angina pectoris can effectively improve the patients’ cardiac function with less adverse reactions and is worthy of clinical application.