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目的:探讨仙元方凝胶剂灌肠治疗小儿腹型过敏性紫癜(HSP)的疗效及安全性。方法:60例腹型HSP患儿,随机平均分为两组,治疗组给予仙元方凝胶剂灌肠治疗,对照组给予注射用甲泼尼龙琥珀酸钠静点,7d内动态观察患儿腹痛缓解情况及血常规、尿常规、便常规、电解质、肝肾功能及凝血功能变化。结果:治疗组和对照组疗效相当,腹痛缓解起效时间对比无显著差异。治疗组血常规中白细胞数量、大便潜血改善程度明显优于对照组(P<0.05)。结论:仙元方凝胶剂灌肠治疗腹型过敏性紫癜能明显改善患儿的消化道症状和实验室指标,未发现不良反应。
Objective: To investigate the efficacy and safety of Xiangyuan Fang gel enema in the treatment of children with abdominal Henoch-Schonlein purpura (HSP). Methods: Sixty children with abdominal HSP were randomly divided into two groups randomly. The treatment group was given Xiangyuan Fang gel enema treatment. The control group was given methylprednisolone sodium succinate injected intravenously. The abdominal pain Relief and blood, urine, routine, electrolytes, liver and kidney function and coagulation changes. Results: The curative effect of the treatment group and the control group was similar, and there was no significant difference in the onset time of relieving abdominal pain. The number of white blood cells and the improvement of fecal occult blood in the treatment group were significantly better than those in the control group (P <0.05). Conclusion: Xian Yuan Fang gel enema treatment of abdominal anaphylactoid purpura can significantly improve children’s gastrointestinal symptoms and laboratory indicators, no adverse reactions were found.