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目的 评价长春地辛对 NSCL C的疗效 ,并观察其在临床应用中的毒副作用。评价长春地辛与 CAP方案联合应用是否有协同作用。方法 6 1例 b期或 期的 NSCL C病人被随机分成两组 :31例病人给 CAP+长春地辛方案治疗 ,30例病人给 CAP方案治疗。两组病人在性别、年龄、一般状况评分、分期、组织学及既往接受化疗各方面具有可比性。结果 CAP+长春地辛组有效率为 41.9%明显高于 CAP组的 16 .7% (P<0 .0 5 )。长春地辛的主要毒副作用为骨髓抑制、轻度周围神经毒性和静脉炎。CAP+长春地辛方案的剂量限制性毒性为骨髓抑制。结论 国产长春地辛对 NSCL C疗效肯定 ,长春地辛与 CAP方案联合治疗 NSCL C具有协同作用 ,取得良好的疗效。毒副作用可以耐受。
Objective To evaluate the curative effect of vindesine on NSCL C and to observe its toxicity in clinical application. Evaluate whether vindesine and CAP regimen have synergistic effects. Method 6 One patient with stage b or stage NSCL C was randomized into two groups: 31 patients treated with CAP + vindesine and 30 patients treated with CAP. The two groups of patients were comparable in terms of gender, age, general condition score, staging, histology, and past history of chemotherapy. Results The effective rate of CAP + vindesine was 41.9% in CAP group compared with 16.7% in CAP group (P <0.05). The main toxicities of vindesine are myelosuppression, mild peripheral neurotoxicity and phlebitis. The dose limiting toxicity of the CAP + Vindesine regimen is myelosuppression. Conclusion Domestic vindesine is effective in treating NSCL C, and vindesine and CAP regimen in combination with NSCL C have a synergistic effect and good curative effect. Toxic side effects can be tolerated.