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应用B淋巴细胞杂交瘤技术获得了数个胃癌杂交瘤克隆。本文就其中的一个克隆进行了较系统的研究,包括应用该抗体对一部分胃癌及其它肿瘤的免疫组织化学检测。证实83YH_2为新的杂交瘤细胞株;并非HLA及ABO系统的抗体;与CEA无关。83YH_2胃癌单克隆抗体是胃癌相关抗原的抗体。其对应抗原与唾液酸粘蛋白相关。
Several gastric hybridoma clones were obtained using B lymphocyte hybridoma technology. In this paper, a systematic study was performed on one of the clones, including the use of this antibody for immunohistochemical detection of a portion of gastric cancer and other tumors. It was confirmed that 83YH 2 is a new hybridoma cell line; it is not an antibody of HLA and ABO system; it has nothing to do with CEA. The 83YH-2 gastric cancer monoclonal antibody is an antibody to gastric cancer-associated antigen. Its corresponding antigen is associated with sialic acid mucin.