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为了降低慢性肺源性心脏病(以下称慢性肺心病)患者治疗环节中失误,我们采用了uv法,对45名住院的慢性肺心病急性发作期患者进行了57人次(其中12人于入院初和出院前各进行一次氨茶碱的血药浓度的监测(TDM)。结果,半衰期(T1/2):6.204±2.716hr;表现分布容积(vd):0.403±0.083L/kg;清除率(CI):55.387±6.197ml/kg·hr。有关参数与对照组进行比较,P<0.05,差异显著。干扰慢性肺心病急性发作期氨茶碱药代动力学的因素较多。本文仅就相互制约,影响疗效,增加毒性的某些临床病理因素进行了探讨。
To reduce errors in the treatment of patients with chronic cor pulmonale (referred to as chronic cor pulmonale), we used the uv method to treat 57 of 45 hospitalized patients with acute exacerbation of chronic pulmonary heart disease (12 of whom were admitted early (TDM), and the half-life (T1 / 2): 6.204 ± 2.716hr; the performance volume of distribution (vd): 0.403 ± 0.083L / kg; clearance rate CI): 55.387 ± 6.197ml / kg · hr.The parameters were compared with the control group, P <0.05, the difference was significant.Acute perturbation of chronic pulmonary heart disease acute aminophylline pharmacokinetic factors are more.This article only mutual Control, affect the efficacy and increase the toxicity of some of the clinicopathological factors were discussed.