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本文合成了一系列氮杂芳香环并哒嗪酮的小分子荧光探针.设计策略主要包括以下两点:1)通过在哒嗪酮4,5-C上并入含氮芳香杂环(吡啶或吡嗪),增强电子受体的吸电子能力;2)末端引入细胞器靶向基团三苯基膦或吗啡啉.这些探针在活细胞成像和脑组织成像上均表现出优良的性质.“,”A series of small-molecular fluorescent probes based on nitrogen-fused pyridazinone scaffold were developed in this report.The design strategy involved two steps:1) enhancing the electron-withdrawing ability of the acceptor by incorporating an N-heterocyclic aromatic ring (pyridine or pyrazine) at the C4 and C5 positions of the pyridazinone skeleton and 2) anchoring a triphenylphosphine or morpholine tail as the subceilular targeting group.These fluorescent probes displayed excellent properties in live cell and brain tissue imaging.