吡喹酮(1)是由Merck和Bayer公司联合开发的令人鼓舞的驱蠕虫药,它广泛用于治疗人和牲畜的血吸虫病和绦虫病,其广谱的作用和高度的活性使之成为值得研究其合成方法的目标。开始采用异喹啉为起始原料,通过多步反应合成1的方法已有专利介绍,人们仍希望有一个适用于工业生产的更直接的合成方法,最近文献报道了两条不同的路线。 Praziquantel (1) is an encouraging anthelmintic developed jointly by Merck and Bayer, and is widely used in the treatment of schistosomiasis and taeniasis in humans and livestock, and its broad spectrum of actions and high levels of activity make it It is worth studying the goal of its synthesis method. Starting with isoquinoline as a starting material, the synthesis of 1 by a multi-step reaction has been patented, and one would still prefer to have a more straightforward synthesis method suitable for industrial production. Two different routes have recently been reported in the literature.