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目的:观察一枝黄花皂苷对小鼠腹腔注射的急性毒性,测定半数致死量(LD_(50))。方法:测出腹腔注射一枝黄花皂苷的LD_(100)为4.0g/kg,按1:0.8的组间距设6个组,采用Bliss法测定腹腔注射LD_(50)。结果:一枝黄花皂苷腹腔注射LD_(50)为2.9g/kg,95%可信限为2.6～3.2g/kg。结论:一枝黄花皂苷预期临床应用安全性良好,但较大剂量可显示一定的毒性作用。
OBJECTIVE: To observe the acute toxicity of saponin from saponin to mice injected intraperitoneally and determine the LD 50 (50). Methods: The LD_(100) of saponin was measured by intraperitoneal injection of 4.0g/kg. Six groups were set up according to the interval of 1:0.8. The LD_(50) was measured by Bliss method. RESULTS: The LD 50 of saponin was 2.9 g/kg intraperitoneally, with a 95% confidence limit of 2.6-3.2 g/kg. Conclusion: Scutellaria saponins is expected to have good clinical safety, but larger doses may show certain toxic effects.