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人乳头瘤病毒(human papillomavirus,HPV)感染与宫颈癌的发生密切相关,预防性HPV疫苗是一种预防宫颈癌的新方法 ,其效果得到了多项临床试验的肯定。现综述HPV感染情况及其致癌机制,HPV疫苗的作用机制、有效性和安全性,并且对疫苗的应用和发展提出了展望。
Human papillomavirus (HPV) infection is closely related to the occurrence of cervical cancer. The preventive HPV vaccine is a new method to prevent cervical cancer, and its efficacy has been affirmed by many clinical trials. This review summarizes the HPV infection and its mechanism of carcinogenesis, the mechanism, effectiveness and safety of HPV vaccines, and puts forward the prospect of its application and development.