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高血压是慢性肾损伤的重要原因,抗高血压治疗能够降低肾功能衰竭的发生率。曾有报道认为β受体阻断剂可能诱发肾功能恶化,同时也有数据表明血管紧张素受体拮抗剂氯沙坦有肾脏保护作用。此前在比索洛尔与肾功能之间相互关系的研究只进行了短期或中期给药。这项研究的目的是比较比索洛尔与氯沙坦在高血压患者中用药一年后抗高血压的疗效及对肾脏与心脏血流动力学的影响。
Hypertension is an important cause of chronic kidney injury, antihypertensive treatment can reduce the incidence of renal failure. It has been reported that β-blockers may induce deterioration of renal function, there are also data show that the angiotensin receptor antagonist losartan renal protective effect. Previous studies of the relationship between bisoprolol and renal function have only been administered in short or medium term. The aim of this study was to compare the effects of bisoprolol and losartan on the antihypertensive efficacy and on renal and cardiac hemodynamics one year after treatment in hypertensive patients.