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动脉粥样硬化(atherosclerosis,AS)是一种累及全身大中动脉的慢性、非可控性血管炎症病变。当高脂血症、高血压和糖尿病等多种危险因素影响而导致动脉内膜受损,引起炎症反应时,大量的细胞因子作用下,例如ICAM-1、VCAM-1、肿瘤坏死因子(TNFα)、白细胞介素-8(IL-8)和白细胞介素-6(IL-6),单核细胞大量地黏附于内皮细胞上,并且移入内膜下,成为巨噬细胞,通过吞噬氧化修饰的低密度脂蛋白形成斑块内泡沫细胞,
Atherosclerosis (AS) is a chronic, uncontrollable vascular inflammatory disease involving the middle and large arteries of the body. When a large number of cytokines, such as ICAM-1, VCAM-1 and tumor necrosis factor (TNFα) are involved in the intimal hyperplasia caused by various risk factors such as hyperlipidemia, hypertension and diabetes, ), Interleukin-8 (IL-8) and interleukin-6 (IL-6), monocytes adhere significantly to endothelial cells and migrate into the intima to become macrophages, which are modified by phagocytic oxidation Low density lipoprotein to form plaque foam cells,