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目的：介绍目前国内外脂质体经皮给药的研究进展。方法：查阅国内外文献报道。结果与结论：通过多种动物模型对脂质体经皮吸收的机制进行了研究，除了药物本身性质外，脂质体促进药物的经皮吸收与脂质体组成、粒径、相态有关，也与给药方式有关，失水保持一定的渗透压差有利于经皮吸收。研究中难以制得热力学活性相同的对比制剂，目前对比制剂仅是药物浓度相同，因此脂质体促进透皮效果的结论尚存争议。
Objective: To introduce the research progress of transdermal delivery of liposomes at home and abroad. Methods: Access to domestic and foreign literature. RESULTS AND CONCLUSION: The mechanism of percutaneous absorption of liposomes was studied through a variety of animal models. In addition to the nature of the drug, liposomes promote percutaneous absorption of the drug is related to liposome composition, particle size, phase state, Also related to the mode of administration, loss of water to maintain a certain degree of osmotic pressure is conducive to percutaneous absorption. In the study, it is difficult to obtain the same thermodynamic activity of the control preparations, the current contrast agent is only the same drug concentration, liposomes to promote the transdermal effect of the conclusion is controversial.