目的探讨宫颈环形电切术(LEEP)与(广泛)子宫切除术的时间间隔对术后并发症的影响。方法回顾性分析上海交通大学附属国际和平妇幼保健院2008年1月至2014年7月接受LEEP术后再行(广泛)子宫切除术的478例患者临床资料,按照LEEP与(广泛)子宫切除术时间间隔分为2组:A组0~2周(n=118),B组>2周(n=360)。比较两组患者术中出血量、住院时间、术后并发症的发生情况及其与时间间隔的相关性。结果 A组术中出血量较B组增多,住院时间明显延长(P<0.05),两组术后发热、尿路感染等并发症发生率比较差异均无统计学意义(P>0.05)。按照手术方式、手术范围分层分析显示,两组术中出血量、术后发热、住院时间比较,差异均无统计学意义(P>0.05)。多因素非条件Logistic回归分析显示,伤口感染是术后发热的独立危险因素(P<0.05),LEEP术和(广泛)子宫切除术的时间间隔与术后发热无显著相关性(P>0.05)。结论 LEEP术和(广泛)子宫切除术的时间间隔与术后并发症发生率无相关性,临床上可根据患者的病情及需求选择广泛性子宫切除术的最佳手术时机。 Objective To investigate the effect of cervical ring excision (LEEP) and (extensive) hysterectomy on postoperative complications. Methods The clinical data of 478 patients underwent LEEP (extensive) hysterectomy from January 2008 to July 2014 in International Peace Maternity and Child Care Hospital affiliated to Shanghai Jiaotong University were retrospectively analyzed. According to the results of LEEP and (extensive) hysterectomy The time intervals were divided into two groups: group A for 0 to 2 weeks (n = 118) and group B for> 2 weeks (n = 360). The incidence of bleeding, hospital stay, postoperative complications and their correlation with time interval were compared between the two groups. Results The blood loss in group A was more than that in group B, and the hospitalization time was significantly longer (P <0.05). There was no significant difference in the incidence of postoperative fever, urinary tract infection and other complication between the two groups (P> 0.05). According to the operation method and stratified analysis of surgical range, there was no significant difference between the two groups in the amount of blood loss, postoperative fever and hospital stay (P> 0.05). Multivariate non-conditional logistic regression analysis showed that wound infection was an independent risk factor for postoperative fever (P <0.05). There was no significant correlation between LEEP surgery and (extensive) hysterectomy and postoperative fever (P> 0.05) . Conclusions There is no correlation between the time interval of LEEP and (extensive) hysterectomy and the incidence of postoperative complications. Clinically, the optimal timing of surgery for extensive hysterectomy can be selected according to the patient ’s condition and needs.