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目的分析部分食管癌高发区各种水的致突变性及致癌性。方法采用蚕豆根尖细胞微核试验作为化学致突变物、致癌物的初筛试验。结果各种类型的水样诱发的蚕豆根尖细胞微核率分别为:煤矿排污水14.42‰,红旗渠水8.62‰,河水8.34‰,深机井水2.81‰,自来水3.96‰。结论煤矿排污水诱变性最高,其次是红旗渠水源水和浊漳河水,而林州市深机井水和自来水诱变性较低。提示,饮用高诱变水可能是食管癌的危险因素之一。
Objective To analyze the mutagenicity and carcinogenicity of various kinds of water in high incidence areas of esophageal cancer. Methods Vicia faba root tip cell micronucleus test as a chemical mutagens, carcinogens preliminary screening test. Results The micronuclei rates of Vicia faba root tip cells were 14.42 ‰, 8.62 ‰, 8.34 ‰, 2.81 ‰ and 3.96 ‰ respectively. Conclusions Coal mine drainage water has the highest mutagenicity, followed by Hongqiqu source water and Zhuozhanghe river water, while Linzhou deep well water and tap water have low mutagenicity. Tip, drinking high mutagenic water may be one of the risk factors for esophageal cancer.