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本文对60例经过3—4个疗程海群生(DEC)治疗后微丝蚴血症复现者用单剂量伊维菌素和标准疗程DEC的疗效比较。用随机抽样,双盲法进行实验。两种治疗组病人均出现完全而短暂的清除微丝蚴血症的作用。一年后,采用伊维菌素治疗组中7例复现微丝蚴血症,DEC组为5例,疗前微丝蚴密度高的患者,疗后一年微丝蚴血症复现也多。两治疗组的副作用均轻微,伊维菌素组常出现发热反应,DEC组则常出现淋巴丝虫病的局部反应。 我们认为伊维菌素是一种有效而实用、可替代DEC治疗班氏丝虫病微丝蚴血症复现者的药物。
This article on the 60 cases after 3-4 courses of sea Qun (DEC) treatment of microfilariaemia recurrence with a single dose of ivermectin and standard course of treatment of DEC compared. Using random sampling, double-blind experiment. Patients in both treatment groups had a complete and transient effect of clearing microfilaremia. One year later, 7 cases of recurrence of microfilaremia were treated with ivermectin in the DEC group and 5 cases with the high density of microfilariae before treatment. One year after treatment, microfilariae recurrence was also observed many. Side effects were mild in both treatment groups, with fever in the ivermectin group, and in the DEC group, local reactions in lymphatic filariasis. We believe that ivermectin is a potent and practical drug that can replace DEC in treating microfilaremia of Bancroftian filariasis in DEC.