1980年Furchgott及Zawadzki首次报道去除内皮后,可阻抑由乙酰胆碱所致离体动脉的舒张,认为内皮存在一种内皮衍生松弛因子(Endotheliumde rived relaxing factor, EDRF),由此引起血管生理学家及药理学家的关注。该氏并对EDRF的来源作过种种推侧,从离体平滑肌实验中排除了缓激肽、前列环素、CAHP及CGMP,因这些物质的作用微弱或基本无作用,腺苷和5′-AMP的最大效应亦远低于乙酰胆碱;消炎痛与阿司匹林则并不影响乙酰胆碱 In 1980, Furchgott and Zawadzki first reported that the removal of endothelium can suppress the relaxation of isolated arteries caused by acetylcholine, suggesting that there is an endothelium-derived relaxing factor (EDRF) in the endothelium, which leads to the development of vascular physiologists and pharmacology Scholar’s attention. The sources of EDRF were variously pushed and bradykinin, prostacyclin, CAHP, and CGMP were excluded from in vitro smooth muscle experiments because of the weak or no effect of these agents. The effects of adenosine and 5’- The maximum effect of AMP is also much lower than that of acetylcholine; indomethacin and aspirin do not affect acetylcholine