氯霉素第一次是由Ehrich等人于1947年从一种土壤菌——委内瑞拉链霉菌分离出来的.它是第一个“广谱”抗生素,作用于需氧和厌氧的革蓝氏阳性和阴性菌,立克次氏体和衣原体.由于它有抗菌谱广,可口服,并能有效地进入身体各部分组织,价钱便宜以及使用很安全等优点而在世界范围内获得应用.不幸的是,其主要的毒性也在开始使用的头二十年里为人们所认识:与剂量无关的致命的再生障碍性贫血,与剂量和时间有 Chloramphenicol was isolated for the first time by Ehrich et al. From a soil strain of Streptomyces tenutiae in 1947. It is the first “broad spectrum” antibiotic to act on aerobic and anaerobic leathers Blue positive and negative bacteria, Rickettsia and Chlamydia. Due to its broad antibacterial spectrum, orally available, and can effectively enter various parts of the body tissue, the advantages of cheap and safe to use in the world, access to Unfortunately, its major toxicity is also well known in the first two decades of use: deadly aplastic anemia unrelated to dose, with dose and time