【摘 要】
：
Although monkeys and pigs can be in-fected with SARS-CoV-2,they generally have a long growth cycle and a large size that is difficult to handle in large quan-ti
【机 构】
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Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key
论文部分内容阅读
Although monkeys and pigs can be in-fected with SARS-CoV-2,they generally have a long growth cycle and a large size that is difficult to handle in large quan-tities.However,the readily available rats and mice are not susceptible to SARS-CoV-2 because of differences in ACE2(angiotensin-converting enzyme 2),the receptor mediating cell entry of SARS-CoV-2[1].Thus,the key to establish-ing a mouse model of COVID-19 is to make the mice express human ACE2 pro-tein,and therefore become SARS-CoV-2 susceptible.
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